GSK-J5 (hydrochloride) |
| カタログ番号GC43794 |
GSK-J5（塩酸塩）は、不活性なGSK J2の細胞透過性エステル誘導体です。 GSK-J5（塩酸塩）もGSK-J4の異性体であり、しばしばネガティブグループとして使用されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797983-32-4
Sample solution is provided at 25 µL, 10mM.
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The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.
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