IRAK4-IN-1 |
| カタログ番号GC31688 |
IRAK4-IN-1 は、7 nM の IC50 を持つインターロイキン 1 受容体関連キナーゼ 4 (IRAK4) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1820787-94-7
Sample solution is provided at 25 µL, 10mM.
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IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) [1].
Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h[1].
[1]. Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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