JAK1-IN-4 |
| カタログ番号GC33258 |
JAK1-IN-4 は強力かつ選択的な JAK1 阻害剤であり、IC50 は JAK1、JAK2、および JAK3 に対してそれぞれ 85 nM、12.8 μM、および >30 μM です。 JAK1-IN-4 は、NCI-H 1975 細胞の STAT3 リン酸化を阻害します (IC50、227 nM)。
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Cas No.: 2091134-35-7
Sample solution is provided at 25 µL, 10mM.
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JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].
[1]. Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak.
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