JQ-1 carboxylic acid |
カタログ番号GC19210 |
(+)-JQ-1 誘導体の一種である JQ-1 カルボン酸は、腫瘍細胞表面の PD-L1 発現をダウンレギュレートするための強力な BET ブロモドメイン阻害剤です。 JQ-1 カルボン酸は、BET ブロモドメインを標的とする PROTAC を合成するための前駆体として使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 202592-23-2
Sample solution is provided at 25 µL, 10mM.
JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.
References:
[1]. James Elliott Bradner, et al. Male contraceptive compositions and methods of use. Patent WO 2011143657 A1.
Average Rating: 5
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