L-902,688 |
カタログ番号GC44023 |
L-902,688 は、0.38 nM の Ki と 0.6 nM の EC50 を持つ強力で選択的な経口活性 EP4 受容体アゴニストです。
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Cas No.: 634193-54-7
Sample solution is provided at 25 µL, 10mM.
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.
Average Rating: 5
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