MAP4343 |
| カタログ番号GC61400 |
MAP4343 は、プレグネノロンの 3-メチルエーテル誘導体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 511-26-2
Sample solution is provided at 25 µL, 10mM.
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MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2].
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro[1].MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells[1].MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells[1]
MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats[2].MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats[2].MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats[2]. Animal Model: Adult Sprague-Dawley male rats with spinal cord injury[2]
[1]. Fontaine-Lenoir V, et, al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4711-6. [2]. Duchossoy Y, et, al. Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone. Brain Res. 2011 Jul 27;1403:57-66.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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