MCHr1 antagonist 2 |
カタログ番号GC31505 |
MCHR1 アンタゴニスト 2 は、メラニン濃縮ホルモン受容体 1 のアンタゴニストであり、IC50 は 65 nM です。 MCHR1 アンタゴニスト 2 は、IMR-32 細胞で 4.0 nM の IC50 で hERG も阻害します 。
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Cas No.: 863115-70-2
Sample solution is provided at 25 µL, 10mM.
MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHr1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.
MCHr1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. MCHr1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells[1].
[1]. Lynch JK, et al. Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84.
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