Methyocarbamol (Synonyms: AHR 85, Guaiacol Glyceryl Ether Carbamate, Guaiphenesin Carbamate, NSC 170960) |
カタログ番号GC16339 |
メチオカルバモールは、経口的に活性な中枢性筋弛緩薬であり、筋肉の Nav1.4 チャネルを遮断します。
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Cas No.: 532-03-6
Sample solution is provided at 25 µL, 10mM.
Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.Target: Carbonic AnhydraseMethocarbamol is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is not hydrolyzed metabolically; metabolism is by Phase I ring hydroxylation and O-demethylation, followed by Phase II conjugation. All the major metabolites are unhydrolyzed carbamates. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm [1, 2].
References:
[1]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6.
[2]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4.
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