ML-179 (Synonyms: CID45100448) |
| カタログ番号GC44215 |
ML-179 (SR-1309) は、IC50 が 320 nM の逆 LRH1 (肝臓受容体ホモログ-1) アゴニストです。 ML-179 は、MDA-MB-231 細胞で抗増殖活性を示します。 ML-179 は、ER 陰性乳癌の研究の可能性を秘めています。
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Cas No.: 1883548-87-5
Sample solution is provided at 25 µL, 10mM.
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ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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