ML 3403 |
| カタログ番号GC50067 |
ML 3403 は、IC50 が 0.38 μM の強力な p38 MAPK 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 549505-65-9
Sample solution is provided at 25 µL, 10mM.
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p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).
Laufer et al (2003) Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 46 3230 PMID:12852754 |Kammerer et al (2007) Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab.Dispos. 35 875 PMID:17344341
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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