MS-1020 |
| カタログ番号GC40791 |
MS-1020 は強力な ATP 競合 JAK3 阻害剤です。 MS-1020 は JAK3/STAT シグナル伝達を阻害し、アポトーシスを誘導します。 MS-1020 は細胞死を促進します。 MS-1020 は、チロシンリン酸化 STAT3 レベルの発現を減少させます。 MS-1020 は、異常な JAK3 シグナル伝達を持つ癌の研究の可能性を秘めています。
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Cas No.: 1255516-86-9
Sample solution is provided at 25 µL, 10mM.
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MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM. It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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