NGI-1 (ML414) (Synonyms: N-linked Glycosylation Inhibitor 1) |
| カタログ番号GC33055 |
NGI-1 (ML414) (ML414) は強力なオリゴサッカリルトランスフェラーゼ (OST) 阻害剤であり、OST 触媒サブユニット STT3A および STT3B の機能を直接標的にして遮断します。 NGI-1 (ML414) は細胞透過性阻害剤であり、細胞の生存率に影響を与えることなく効果的にウイルス感染性を低下させることができます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 790702-57-7
Sample solution is provided at 25 µL, 10mM.
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NGI-1 is a cell permeable inhibitor.
NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].
[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.
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