PD 407824 |
| カタログ番号GC18396 |
PD 407824 は、それぞれ 47 および 97 nM の IC50 を持つチェックポイント キナーゼ Chk1 および WEE1 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 622864-54-4
Sample solution is provided at 25 µL, 10mM.
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PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 uM), Cdk4 (IC50 = 3.75 uM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 uM for all), and other Cdks (IC50s = >50 uM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 uM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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