PF-4693627 |
| カタログ番号GC18700 |
PF-4693627 は、変形性関節症 (OA) および関節リウマチ (RA) によって引き起こされる炎症の治療のための、強力で選択的かつ経口的に生物学的に利用可能なミクロソーム プロスタグランジン E シンターゼ-1 (mPGES-1) 阻害剤 (IC50=3 nM) です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1312815-93-2
Sample solution is provided at 25 µL, 10mM.
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PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM). It is selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values greater than 50 μM, as well as COX-2 in fetal fibroblasts (IC50 = >10 μM). PF-4693627 inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM). In vivo, PF-4693627 (10 mg/kg) inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation.
Review for PF-4693627
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
Review for PF-4693627
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