Rimeporide hydrochloride (EMD-87580 hydrochloride) (Synonyms: EMD-87580 hydrochloride) |
| カタログ番号GC31449 |
リメポリド塩酸塩 (EMD-87580 塩酸塩) (EMD-87580 塩酸塩) は、Na+/H+ 交換体 (NHE-1) の強力かつ選択的な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 187870-95-7
Sample solution is provided at 25 µL, 10mM.
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Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].
[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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