RMM 46 |
| カタログ番号GC50294 |
RMM 46 は、MSK/RSK ファミリー キナーゼに対する選択的かつ可逆的な共有結合阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1307896-46-3
Sample solution is provided at 25 µL, 10mM.
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MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID:23540679
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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