Ro 67-7476 |
カタログ番号GC12485 |
Ro 67-7476 は、mGluR1 の強力なポジティブ アロステリック モジュレーターであり、60.1 nM の EC50 でラット mGluR1a を発現する HEK293 細胞におけるグルタミン酸誘導カルシウム放出を増強します。 Ro 67-7476 は強力な P-ERK1/2 アゴニストであり、グルタミン酸を外から加えなくても ERK1/2 リン酸化を活性化します(EC50=163.3 nM)。
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Cas No.: 298690-60-5
Sample solution is provided at 25 µL, 10mM.
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.target: mGlu1 EC 50: 60.1 nM(1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM.(3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.
References:
[1]. Hemstapat K et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006 Aug, 70(2), 616-26
[2]. Knoflach F et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7.
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