Simeprevir (sodium salt) |
| カタログ番号GC44891 |
シメプレビル (TMC435; TMC435350) ナトリウムは、強力で特異性の高い C 型肝炎ウイルス (HCV) NS3/4A プロテアーゼ阻害剤であり、Ki は 0.36 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1241946-89-3
Sample solution is provided at 25 µL, 10mM.
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Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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