SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide) (Synonyms: (±)-6-chloro-APB) |
| カタログ番号GC33664 |
SKF-82958 ((±)-SKF 82958) 臭化水素酸塩は、ドーパミン D1 受容体の完全アゴニスト (K0.5=4 nM) であり、D2 受容体よりも D1 に対して選択的です (K0.5=73 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74115-01-8
Sample solution is provided at 25 µL, 10mM.
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SKF 82958 hydrobromide is a D1/D5 receptor full agonist. IC50 value:Target: D1/D5 receptorin vitro: Neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum. in vivo:Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP and PPE mRNA expression in the intact rat striatum.
[1]. Wang JQ, et al. The Full D1 Dopamine Receptor Agonist SKF-82958 Induces Neuropeptide mRNA in the Normosensitive Striatum of Rats: Regulation of D1/D2 Interactions by Muscarinic Receptors.J Pharmacol Exp Ther. 1997 May;281(2):972-82.
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