SR 7826 |
カタログ番号GC50219 |
SR 7826 は、LIMK1 の IC50 が 43 nM である、ビスアリール尿素由来の強力で選択的かつ経口的に活性な LIM キナーゼ (LIMK) 阻害剤のクラスです。
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Cas No.: 1219728-20-7
Sample solution is provided at 25 µL, 10mM.
Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID:25621531
Average Rating: 5
(Based on Reviews and 2 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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