Syk Inhibitor II (hydrochloride) (Synonyms: Spleen Tyrosine Kinase Inhibitor II) |
| カタログ番号GC44979 |
脾臓チロシンキナーゼ（Syk）は、リン酸化されるとFcRγ鎖の免疫受容体チロシンベース活性化モチーフに結合し、血小板機能および炎症に関連する下流シグナル伝達を仲介する非受容体型チロシンキナーゼです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 227449-73-2
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).
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