RH01386 |
| カタログ番号GC70570 |
RH01386は、内質網ストレス（ERS）によって誘導されるβ細胞機能障害と死を予防し、アポトーシス促進遺伝子の発現を抑制する小分子である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 301177-36-6
Sample solution is provided at 25 µL, 10mM.
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RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1].
RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1].
References:
[1]. Tran K, et al. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.ACS Chem Biol. 2014 Dec 19;9(12):2796-806.
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