Ritanserin (Synonyms: R-55-667) |
カタログ番号GC13883 |
リタンセリン (R 55667) は、5-HT2 受容体の非常に強力で比較的選択的な経口活性型の長時間作用型アンタゴニストであり、IC50 は 0.9 nM で、ヒスタミン H1、ドーパミン D2、アドレナリン α1、アドレナリン α2 受容体に対する活性は低い .
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Cas No.: 87051-43-2
Sample solution is provided at 25 µL, 10mM.
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1].
Ritanserin (R 55667) is a highly potent, relatively selective, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine-H1 (IC50, 35 nM), Dopamine-D2 (IC50, 70 nM), Adrenergic-α1 (IC50, 97 nM), Adrenergic-α2 receptor (IC50, 150 nM)[1].
References:
[1]. Leysen JE, et al. Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. Mol Pharmacol. 1985 Jun;27(6):600-11.
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