RN 1734 |
| カタログ番号GC17267 |
RN 1734 は TRPV4 チャネルの選択的アンタゴニストであり、TRPV4 の 4αPDD を介した活性化に完全に拮抗し、3 つの種すべてで同等の低マイクロモル IC50 を示します (hTRPV4: 2.3 μM、mTRPV4: 5.9 μM、rTRPV4: 3.2 μM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 946387-07-1
Sample solution is provided at 25 µL, 10mM.
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RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM)[1]. RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells[2].
RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis[2].RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP[2].
RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse[2].
References:
[1]. Kato K, et al. Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: a study to elucidate the action points of acidosis and search for putative target molecules. Eur J Pharmacol. 2011 Aug 1;663(1-3):27-39.
[2]. Liu M, et al. TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2018 Nov 5;12:392.
[3]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.
| Cas No. | 946387-07-1 | SDF | |
| Chemical Name | 2,4-dichloro-N-isopropyl-N-(2-(isopropylamino)ethyl)benzenesulfonamide | ||
| Canonical SMILES | CC(NCCN(S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O)C(C)C)C | ||
| Formula | C14H22CL2N2O2S | M.Wt | 353.31 |
| 溶解度 | ≥ 71 mg/mL in DMSO, ≥ 72 mg/mL in EtOH | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8304 mL | 14.1519 mL | 28.3038 mL |
| 5 mM | 0.5661 mL | 2.8304 mL | 5.6608 mL |
| 10 mM | 0.283 mL | 1.4152 mL | 2.8304 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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