Rubiadin-1-methyl ether (Synonyms: NSC 59063, RBM) |
| カタログ番号GC60331 |
ルビアジン-1-メチルエーテルはモリンダ・オフィシナリス・ハウから分離された天然のアントラキノンであり、NF-κB p65 のリン酸化と IκBα の分解を阻害し、p65 の核移行を減少させることにより、破骨細胞の骨吸収を阻害します。
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Cas No.: 7460-43-7
Sample solution is provided at 25 µL, 10mM.
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Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].
[1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.
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