Rubratoxin A (Synonyms: BRN 1633008, HSDB 3532) |
| カタログ番号GC40285 |
ルブラトキシン A は天然のマイコトキシンであり、170 nM の IC50 を持つプロテインホスファターゼ 2A (PP2A) の競合的阻害剤です。ルブラトキシン A は、マウス異種移植片における腫瘍転移の抑制と原発腫瘍体積の減少を引き起こします。
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Cas No.: 22467-31-8
Sample solution is provided at 25 µL, 10mM.
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Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.
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