S-Adenosyl-L-methionine disulfate tosylate (Synonyms: AdoMet, FO 1561, SAM, SAMe) |
| カタログ番号GC30843 |
S-アデノシル-L-メチオニン二硫酸トシレート (アデメチオニン二硫酸トシレート) は、すべての哺乳動物細胞で合成される主要な生物学的メチル供与体ですが、肝臓で最も豊富に合成されます。
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Cas No.: 97540-22-2
Sample solution is provided at 25 µL, 10mM.
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S-Adenosyl-L-methionine disulfate tosylate is a methyl donor and cofactor. It is involved in a variety of biological processes, including epigenetic regulation, post-translational modification of proteins and metabolism. Preparations containing S-Adenosyl-L-methionine disulfate tosylate have been used as dietary supplements. S-Adenosyl-L-methionine disulfate tosylate also exhibits antiproliferative, pro-apoptotic and anti-metastatic effects in human cancers[1-2].
S-Adenosyl-L-methionine disulfate tosylate (300 μM) can regulate the cell cycle progression of Cal-33 and JHU-SCC-011 cells and reduce the expression of cyclins B1, E1, and D1. S-Adenosyl-L-methionine disulfate tosylate (200 μM and 300 μM) can inhibit the migration of Cal-33 and JHU-SCC-011 cells in a dose-dependent manner after 24 hours and 48 hours, respectively[2]. The combination of 5‑fluorouracil (5-FU) with 5-Adenosyl-L-methionine disulfate tosylate at 5-40 μg/ml can protect the anticancer effect of 5-FU by regulating the expression of DNA methyltransferases (DNMTs)[3].
In the elevated plus maze test, rats given S-Adenosyl-L-methionine disulfate tosylate (100 mg/kg) showed the greatest reduction in transfer latency at day 26, confirming the memory-improving effect of S-Adenosyl-L-methionine disulfate tosylate. Animals treated with 100 mg/kg S-Adenosyl-L-methionine disulfate tosylate showed decreased malondialdehyde and increased glutathione levels, suggesting that S-Adenosyl-L-methionine disulfate tosylate has antioxidant properties in the PTZ-induced rat model. The antioxidant properties of S-Adenosyl-L-methionine disulfate tosylate may improve cognitive impairment caused by oxidative stressl[4]. S-Adenosyl-L-methionine disulfate tosylate (30 mg/kg) can prevent autism spectrum disorder (ASD)-like behaviors caused by early postnatal valproic acid treatment in rat pups[5].
References:
[1] Loenen, W.A.M.S-Adenosylmethionine: Jack of all trades and master of everything?Biochem. Soc. Trans.34(2)330-333(2006).
[2] Mosca L, Minopoli M, Pagano M, Vitiello F, Carriero MV, Cacciapuoti G, Porcelli M. Effects of S-adenosyl-L-methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224.
[3] Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378.
[4] Dhediya RM, Joshi SS, Gajbhiye SV, Jalgaonkar SV, Biswas M. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.
[5] Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74.
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