S-HP210 |
| カタログ番号GC70971 |
S-HP210は要りと部分的な糖質コルチコイド受容体(GR)の19.2亿IC50値μM NF -κB transrepression (TR)。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC50 value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.
References:
[1]. Hu X, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022;237:114382.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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