S-NEPC |
| カタログ番号GC44907 |
アラキドン酸のシトクロムP450代謝物である11（12）-EpETrEおよび14（15）-EpETrEは、血管拡張作用を持つ内皮由来の過分極因子として同定されています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 147349-28-8
Sample solution is provided at 25 µL, 10mM.
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Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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