S1PL-IN-31 (Synonyms: Sphingosine-1-Phosphate Lyase Inhibitor 31; S1PL Inhibitor 31; S1P Lyase Inhibitor 31) |
| カタログ番号GC91424 |
S1PL-IN-31は、スフィンゴシン-1-リン酸（S1P）ライアーゼの阻害剤であり（IC50 = 210 nM）、です。
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Cas No.: 1538574-95-6
Sample solution is provided at 25 µL, 10mM.
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S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM).1 It is also an antagonist of the Smoothened (Smo) receptor (IC50 = 440 nM). In vivo, S1PL-IN-31 (2 mg/kg per day) prevents cervical and thoracic lymphocyte infiltration and neuromuscular weakness in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by the myelin oligodendrocyte glycoprotein (MOG) peptide MOG29-152. It reduces the total number of lymphocytes, as well as the levels of CD4+ T cells, CD8+ T cells, and B cells in rats. S1PL-IN-31 (100 mg/kg) increases S1P levels in the heart and lymph nodes of male and female rats and decreases heart rate in female rats when administered at doses of 3 and 10 mg/kg per day.2
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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