S4 |
| カタログ番号GC50209 |
S4 は、炭酸脱水酵素 IX/XII (CA IX/XII) の強力かつ選択的な阻害剤であり、Ki はそれぞれ 7 nM および 2 nM です。 S4 は CA II と CA I も阻害します (それぞれ Ki = 546 と 5600 nM)。 S4 は、同所性 MDA-MB-231 マウス モデルにおいて、原発腫瘍の成長に影響を与えることなく、肺転移の数を抑制することができます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1330061-67-0
Sample solution is provided at 25 µL, 10mM.
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High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.
Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID:22621623
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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