Sappanchalcone |
| カタログ番号GC64645 |
Caesalpinia sappan L. から分離されたフラボノイドであるサパンカルコンは、ヒト結腸癌細胞でカスパーゼ依存性および AIF 依存性のアポトーシスを誘導します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 94344-54-4
Sample solution is provided at 25 µL, 10mM.
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Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].
Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].
[1]. Seo HW, et al. Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. Chem Biol Interact. 2020;327:109185.
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