SBP-0636457 (Synonyms: SBI-0636457; SB1-0636457) |
| カタログ番号GC63870 |
SBP-0636457 (SB1-0636457) は SMAC 模倣体であり、IAP アンタゴニストです。 SBP-0636457 は、0.27 μM の Ki で IAP タンパク質の BIR ドメインに結合します。 SBP-0636457 は、固形腫瘍および血液がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1422180-49-1
Sample solution is provided at 25 µL, 10mM.
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SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].
SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1].SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC50 of 9 nM[1].
[1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15.
[2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587.
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