SD 0006 (Synonyms: SD-006) |
| カタログ番号GC19325 |
SD 0006 (SD-06) は、p38α MAP キナーゼの経口活性、選択的、ATP 競合的かつ強力なジアリール ピラゾール阻害剤であり、p38α の IC50 は 110 nM です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 271576-80-8
Sample solution is provided at 25 µL, 10mM.
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SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].
SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate[1].
SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy[1].SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling[1].
References:
[1]. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60.
[2]. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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