SDH-IN-2 |
カタログ番号GC71067 |
SDH-IN-2 は有効なコハク酸脱水素酵素(SDH)阻害剤であり、IC 50は0.55μg/mLである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1823354-06-8
Sample solution is provided at 25 µL, 10mM.
SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) completely inhibits Physalospora piricola infection on apples, and also shows high inhibition rates of 70.9-86.9% on all the fungi even at 20 μg/mL[1].
SDH-IN-2 inhibits P. oryza and F. oxysporum f. sp. niveum with EC50s of 4.33 and 3.56 μg/mL[1].
SDH-IN-2 (0-50 μg/mL) has no effect on the germination rate of bean seeds[1].
SDH-IN-2 (0-100 μg/mL) has no significant effect on the growth of wheat seedlings[1].
SDH-IN-2 inhibits SDH enzymatic activity with an IC50 of 0.55 μg/mL[1].
SDH-IN-2 binds well to the ubiquinone-binding region of SDH by hydrogen bonds and undergoes π–alkyl interaction and π-cation interaction[1].
SDH-IN-2 (Compound 13) (0-200 μg/mL, 7 days) inhibits the infection of P. piricola on apples[1].
References:
[1]. Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71(8):3681-3693.
Average Rating: 5
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