SDZ-MKS 492 (Synonyms: MKS 492) |
| カタログ番号GC65302 |
SDZ-MKS 492 (MKS 492) は、サイクリック GMP 阻害ホスホジエステラーゼ (タイプ III PDE) の選択的阻害剤です。
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Cas No.: 114606-56-3
Sample solution is provided at 25 µL, 10mM.
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SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].
MKS 492 relaxes airway smooth muscle in vitro[2].
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1].
[1]. Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13.
[2]. Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.
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