Semaglutide Side Chain |
| カタログ番号GC91493 |
Semaglutide side chain is a synthetic intermediate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1118767-16-0
Sample solution is provided at 25 µL, 10mM.
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Semaglutide side chain is a synthetic intermediate.[1] It has been used as an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide , as well as a lipid side chain to increase the proteolysis-resistance of insulin derivatives for use in vivo.[1],[2]
References:
[1].Guryanov, I., Orlandin, A., De Paola, I., et al.Copper(II) lysinate and pseudoproline assistance in the convergent synthesis of the GLP 1 receptor agonists liraglutide and semaglutideOrg. Process Res. Dev.25(7)1598-1611(2021).
[2].Kjeldsen, T.B., Hubálek, F., Tagmose, T.M., et al.Engineering of orally available, ultralong-acting insulin analogues: Discovery of OI338 and OI320.J. Med. Chem.64(1)616-628(2021).
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