Sermorelin (trifluoroacetate salt) |
| カタログ番号GC44883 |
セルモレリンは、成長ホルモン放出ホルモン（GHRH）の29残基N末端アナログであり、成長ホルモン（GH）放出を刺激する能力を保持しています。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release. Sermorelin (1 μg/kg, i.v.) increases serum GH levels in rats by approximately 17% compared with saline control after 15 minutes. It also increases GH release in pigs when administered at a dose of 250 ng/kg. Sermorelin (1 μM) increases proliferation of NCI-H727 human bronchial carcinoid cells by 30% and increases vascular endothelial growth factor (VEGF) secretion. It increases phosphorylation of focal adhesion kinase (FAK) and expression of VEGF in A549 lung cancer cells when used at a concentration of 0.1 μM. Formulations containing sermorelin have been used to diagnose and treat growth hormone deficiency.
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