SIRT-IN-3 |
| カタログ番号GC61279 |
SIRT-IN-3 は強力な SIRT 阻害剤であり、SIRT1 の IC50 は 17 μM です。 SIRT-IN-3 は、SIRT2 および SIRT3 よりも SIRT1 に対してそれぞれ約 4 倍および 14 倍の選択性を示します (SIRT2 および SIRT3 に対してそれぞれ 74 μM および 235 μM の IC50 )。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1211-19-4
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].
SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].
[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *