SL 01 (Synonyms: NSC 251810, SL 01, Z-L-Phe Chloromethyl Ketone, ZPCK) |
| カタログ番号GC44897 |
SL 01 は、経口バイオアベイラビリティを改善するために設計されたゲムシタビンの経口活性プロドラッグです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26049-94-5
Sample solution is provided at 25 µL, 10mM.
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SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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