SLM6031434 (hydrochloride) |
| カタログ番号GC46222 |
SLM6031434 (塩酸塩) は、mSphK2、rSphK2、mSphK1、および rSphK1 に対してそれぞれ 0.4 μM、0.5 μM、>20 μM、22 μM の Kis を持つ、選択性の高いスフィンゴシンキナーゼ 2 (SphK2) 阻害剤です。
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Cas No.: 1897379-34-8
Sample solution is provided at 25 µL, 10mM.
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SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).1 It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.
|1. Kharel, Y., Morris, E.A., Congdon, M.D., et al. Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J. Pharmacol. Exp. Ther. 355(1), 23-31 (2015).
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