SLM6031434 |
| カタログ番号GC44901 |
SLM6031434は、スフィンゴシンキナーゼ2（SPHK2）の選択的阻害剤であり（マウス再構成SPHK2およびSPHK1に対してKis = 0.4および> 20μM）、その効果が認められています。
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Cas No.: 1897379-33-7
Sample solution is provided at 25 µL, 10mM.
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SLM6031434 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Kis = 0.4 and >20 μM for mouse recombinant SPHK2 and SPHK1, respectively). It decreases sphingosine-1-phosphate and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces serum levels of S1P in SPHK1-/- but not SPHK2-/- mice. In wild-type mice and rats, SLM6031434 increases serum levels of S1P in a time-dependent manner.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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