Spadin TFA |
| カタログ番号GC61288 |
血中に放出されたプロペプチドに由来する天然ペプチドである Spadin TFA は、10 nM の IC50 値を持つ強力な TREK-1 チャネル遮断薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice[1].
[1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.
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