SSTR5 antagonist 2 hydrochloride |
| カタログ番号GC64259 |
SSTR5 アンタゴニスト 2 塩酸塩は、非常に強力な経口活性および選択的ソマトスタチン (受容体) サブタイプ 5 (SSTR5) アンタゴニストであり、2 型糖尿病 (T2DM) の研究の可能性があります 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2988224-31-1
Sample solution is provided at 25 µL, 10mM.
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SSTR5 antagonist 2 hydrochloride is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of type 2 diabetes mellitus (T2DM)[1].
SSTR5 antagonist 2 (compound 10) (10 mg/kg, orally) hydrochloride increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].SSTR5 antagonist 2 hydrochloride increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].
[1]. Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018;9(11):1082-1087. Published 2018 Sep 12.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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