STAT3-IN-15 |
カタログ番号GC71187 |
STAT3-IN-15は、特発性肺線維症(ipf)に対する強力かつ経口活性のstat3阻害剤です。
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Sample solution is provided at 25 µL, 10mM.
STAT3-IN-15 (compound 10k) inhibits NIH-3T3 cell proliferation with an IC50 of 0.47 μM[1].
STAT3-IN-15 forms hydrogen bonds with Lys591 and Ser636, occupying the pY subpocket of STAT3[1].
STAT3-IN-15 (0-100 nM, 72 h) inhibits fibroblast activation and proliferation[1].
STAT3-IN-15 (50 nM, 24 h) inhibited TGF-β1 (5 ng/mL)-induced activation of NIH-3T3 cells[1].
STAT3-IN-15 (200 nM, 24 h) blocks TGF-β1 induced EMT process in A549 cells, determined by morphological changes[1].
STAT3-IN-15 (compound 10k) (30 and 60 mg/kg, intragastric administration) alleviates Bleomycin.html" class="link-product" target="_blank"> Bleomycin -induced pulmonary fibrosis in mouse[1].
References:
[1]. Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2022 Nov 28;246:114953.
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