STING agonist-1 (Synonyms: STING Agonist-1) |
カタログ番号GC12943 |
STING アゴニスト-1 (G10) は、新興アルファウイルスに対する抗ウイルス活性を誘発するヒト特異的 STING アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 702662-50-8
Sample solution is provided at 25 µL, 10mM.
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].G10 is an indirect activator of human STING-dependent phenotypes[1].G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].G10 induces innate antiviral mRNA expression in primary human cells[1].
References:
[1]. Sali TM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.
Average Rating: 5
(Based on Reviews and 36 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *