T-26c |
| カタログ番号GC31862 |
T-26c は、6.75 pM の IC50 と他の関連する金属酵素よりも 2600 倍以上の選択性を持つ、非常に強力で選択的なマトリックスメタロプロテイナーゼ-13 (MMP-13) 阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869296-13-9
Sample solution is provided at 25 µL, 10mM.
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T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1].
[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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