TAN 1364B (Synonyms: RK-682 (rac-1)) |
| カタログ番号GC41443 |
RK-682 のラセミ体である TAN 1364B は、タンパク質チロシンホスファターゼ (PTPase) 阻害剤です。 TAN 1364B は、8.6 μM、12.4 μM、および 0 の IC50 で、プロテイン チロシン ホスファターゼ 1B (PTP-1B)、低分子量プロテイン チロシン ホスファターゼ (LMW-PTP)、および細胞分裂周期 25B (CDC-25B) を阻害します。 μM、それぞれ。
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Cas No.: 154639-24-4
Sample solution is provided at 25 µL, 10mM.
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TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
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