Tanomastat (Synonyms: BAY 12-9566) |
カタログ番号GC44990 |
タノマスタット (BAY 12-9566) は、Zn 結合カルボキシル基を持つ、経口で生物学的に利用可能な非ペプチド性ビフェニル マトリックス メタロプロテイナーゼ (MMP) 阻害剤です。 Ki 値は、MMP-2、MMP-3、MMP-9、MMP-13 でそれぞれ 11、143、301、および 1470 nM です。タノマスタットは、いくつかの実験的腫瘍モデルで抗浸潤および抗転移活性を示します。
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Cas No.: 179545-77-8
Sample solution is provided at 25 µL, 10mM.
Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively). It is active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients.
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