TAPI 0 |
| カタログ番号GC50189 |
TAPI 0 は、100 nM の IC50 を持つ TACE (TNF-α 変換酵素; ADAM17) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 163958-73-4
Sample solution is provided at 25 µL, 10mM.
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ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.
Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 281 16691 PMID:16565079 |Rzeniewicz et al (2015) L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 112 E1461 PMID:25775539
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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